Deep space, at the edge of the galaxy. The future. A new prisoner arrives on top security prison ship and psychiatric research unit Dante 01. Sole survivor of an encounter with an alien force beyond imagining, Saint Georges is a man possessed by inner demons, caught up in the battle to control the monstrous power within him. It's a power that will infect the other highly dangerous occupants of Dante 01, gaolors and prisoners alike, unleashing a violent rebellion that turns this terrifying, labyrinthine world upside down. In the otherworldly hell of the ship's depths, through danger and redemption, each must journey to his very limits... each must confront his own Dragon.

In Paris, many citizens go to the precinct after the doors of their apartments have been sprayed with a 4 and the letters "clt". When a dweller is found mysteriously dead in his apartment, Detective Jean-Baptiste Adamsberg and his partner Danglard investigate the case and discover that plague may have killed the victim. Meanwhile, in the center of Paris, the former actor Joss Le Guern survives reading advertisements in a square for the public; when he receives weird messages about an outbreak of plague that is coming to Paris, the former professor Hervé Decambrais requests the warnings and goes to the library to research the meaning of the text, where he meets Adamsberg. Together they find that a maniac is killing people using flees contaminated by rats and spreading the disease in the city; without any clue, the police force do not have how to avoid the panic in Paris.

The charismatic criminal Dobermann, who got his first gun when he was christened, leads a gang of brutal robbers...